Igtrin™ | IGF-1 LR3 (Long Arginine 3-IGF-1)

ABOUT IGTRIN

The engineered IGF-1 analogue LR3

IGF-1 LR3 (Long Arginine 3-IGF-1) is an 83-amino-acid analogue of human insulin-like growth factor 1, carrying an arginine substitution at position 3 and a 13-residue N-terminal extension. These modifications sharply reduce its affinity for IGF-binding proteins while preserving receptor activity, giving the analogue markedly higher biological potency than native IGF-1 in experimental systems.

Because it remains free rather than sequestered by binding proteins, IGF-1 LR3 is a standard growth supplement in serum-free cell-culture media and a widely used tool in growth-factor research. Igtrin™ supplies it as a defined, batch-documented reference material with identity and purity verified on every lot.

83AA

IGF-1 ANALOGUE

100 MCG

PER VIAL

2–8°C

COLD CHAIN

IGF-1 LR3 analogue research illustration

RESEARCH BACKGROUND

Engineered potency, three decades of use

IGF-1 LR3 emerged from work in Adelaide in the early 1990s, where recombinant IGF-1 analogues were engineered to escape the binding proteins that normally sequester IGF-1. The landmark 1992 study showed that LR3-IGF-1 binds IGF-binding proteins poorly while retaining receptor activity — making it substantially more potent than native IGF-1 in cell-based assays.

Since then, IGF-1 LR3 has become a workhorse of growth-factor research and biomanufacturing, most prominently as a media supplement sustaining growth and productivity of CHO and other production cell lines. It remains among the most used IGF-1 analogues in the published literature.

PRIMARY REFERENCE

Francis GL, Ross M, Ballard FJ, Milner SJ, Senn C, McNeil KA, Wallace JC, King R, Wells JRE. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. J Mol Endocrinol. 1992;8(3):213–223.

CRC for Tissue Growth and Repair, Adelaide, Australia

DOI: 10.1677/JME.0.0080213

Reference provided for scientific context only. Igtrin™ is analytical grade, for research and analytics only, and is not a medicinal product. CoreyPauling is not affiliated with the cited study or its sponsors.

PRODUCT SPECIFICATIONS

Igtrin™ at a glance

Product name Igtrin™

Active substance IGF-1 LR3 — Long Arginine 3-IGF-1, an 83-amino-acid analogue of human IGF-1

Strength 100 mcg per vial

Form Lyophilised powder for reconstitution

Presentation Multi-dose glass vial

Pack size 10 vials per foil sachet

Origin Recombinant analogue of naturally occurring human insulin-like growth factor 1

Storage Store cold at 2–8°C; stable refrigerated for full shelf life, near-stable over 90 days at room temperature

Intended use Analytical grade · For research and analytics only · For export only

Documentation Batch-specific Certificate of Analysis

RESEARCH KEYPOINT Research found the benefit of IGF-1 LR3 in helping achieve enhanced biological potency through poor IGF-binding-protein affinity with retained receptor activity, based on the landmark 1992 J Mol Endocrinol study (Francis et al., Adelaide).

OUR TECHNOLOGY

Pressurized Dark-Room Fragmented Lyophilization

Igtrin™ is lyophilised using CoreyPauling's proprietary Pressurized Dark-Room Fragmented Lyophilization process, which protects the protein from light and oxidative stress during freeze-drying. The result is stability that conventional lyophilisates cannot match.

90+ days

Near-stable at room temperature

The lyophilised powder remains almost fully stable for over 90 days at room temperature — forgiving of transit delays and customs holds without loss of integrity.

3 years

Stable in cold storage

Stored cold at 2–8°C, Igtrin™ retains full stability for the shelf life stated on every label, from the date of manufacture.

Igtrin™ is analytical grade only. CoreyPauling does not encourage or support its use in humans or veterinary applications.

QUALITY & MANUFACTURING

Every batch documented

STD

International standards

Manufactured under internationally recognised quality standards with controlled environments and validated processes at every production step.

HPLC

Analytical verification

Identity, purity and content are verified by HPLC and complementary analytical methods before any batch is released.

LOT

Full traceability

Lot, manufacturing and expiry data are printed on every sachet and vial, tied to batch records and the Certificate of Analysis.

STORAGE & HANDLING

Cold chain, door to door

Store cold at 2–8°C

Keep refrigerated for full shelf life. Do not freeze. Protect vials from light and keep them in the original sachet until use; brief room-temperature excursions are tolerated thanks to our lyophilization process.

Insulated export shipping

Wholesale consignments ship in insulated packaging with cooling elements and temperature indicators, with export documentation prepared per destination.

FAQ

Frequently Asked Questions

Igtrin™ is available exclusively through authorized retailers and distributors. Contact our wholesale team to be directed to an authorized retailer in your region.

No. CoreyPauling supplies wholesale quantities to distributors and authorized retailers only.

MOQ depends on destination and packaging configuration. Standard wholesale units are sachets of 10 vials; contact us with your required volume for tiered pricing.

Yes. Every batch ships with a batch-specific Certificate of Analysis covering identity, purity and content, referenced to the lot number printed on the sachet and vial labels.

Commercial invoice, packing list and Certificate of Analysis are standard. Additional documentation can be prepared according to the import requirements of the destination country.

CoreyPauling peptide manufacturing laboratory

ABOUT COREYPAULING

Science · Innovation · Quality · Trust

CoreyPauling is a US–Singapore based biotechnology company developing and supplying research-grade peptides and proteins to distributors and laboratories worldwide. Grounded in scientific rigour and international manufacturing standards, the brand stands for precision, continuous innovation and long-term reliability.

Igtrin™ sits alongside the wider CoreyPauling catalogue — including Somapin™, Bepeci™, Retatride™, Tesamore™, Thymob™, Lorenpickart™, Kaypv™, Menotrope™ and Pregnil™ — all supplied under the same documentation and cold-chain standards.

Every batch of Igtrin™ is manufactured at the CoreyPauling facility. Full company information, the complete product catalogue and manufacturing capabilities are available on the official factory website at coreypauling.com.

VISIT COREYPAULING.COM

WHOLESALE INQUIRY

Distribute Igtrin™

For quotations, batch documentation, certificates of analysis and export terms, contact our wholesale team. Please include your company details, destination country and required quantities.

support@coreypauling.com